Abnormal Leydig cells. Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis. Conversely, inducible deletion of Foxl2 in adult mouse ovarian follicles leads to upregulation of Sox9 and reprogramming of adult ovaries to testes
From Wikipedia, the free encyclopedia. The external genitalia consist of all the external reproductive structures. Scientific Reports. J Neurobiol. Sexual dimorphism is also observed in the human brain. Sex differences in the animal brain Central nervous system exhibits structural and behavioral differences between genders due to exposure to sex steroid hormones during gestation.
Wolffian ducts Wolffian ducts are present in the embryo at a crown-rump length of mm, and serve as the excreting duct to the mesonephros. Dax1 antagonizes Sry action in mammalian sex determination. At birth, this number has fallen to 2 millions and, at 7 years of age, to1.
Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Male orientation of the urogenital sinus is characterized by prostatic development and by the repression of vaginal development. Ottolenghi C, McElreavey K.
In fact, while fetal testis development progresses normally in the absence of germ cells , ovarian follicles do not develop when germ cells are absent , Sexual endocrinology of fetal and perinatal life. In contrast, the development of the testes is not hindered by the lack of germ cells Normal androgen physiology in mammals.